Sometimes, you kind of can. And I'd like to see this reflected more in alternate history.Also, Middle East was the centre of learning and a place with an overabundance of polities and wars. All of those make prophets and religions appearing easier. In fact, the last two are exactly what caused the first one. Well, dont take it as a fact, i think it's just one of the mainstream theories, but philospohy and science generally developed in places that were disunited; Ancient Greece, Classical India, Muslim World (Which by the time of the Islamic Golden Age had truly disunited) etc. Imagine you are an Athenian scholar, and you propose X theory, which the Athenian oligarchs dont like. Well, you can simply move to Sparta, or Thebes, or any of the hundreds of other city-states and find a ruler atleast willing to tolerate you. The Middle East also sat on many trade routes, which allowed for goods and ideas to be exchanged. That's why Aleppo had far more thinkers and learners than Mogadishu or Ulanbaatar.
For example, once upon a time, the biggest and wealthiest city in the New World was Caracas, Venezuela -- but the city was devastated by the Latin American wars for independence, the subsequent political upheaval and civil wars, and finally the 1812 earthquake. Caracas never recovered, while places like Mexico City, Rio de Janeiro, and New York grew instead.
Throughout the Middle Ages and Early Modern Period, the biggest and wealthiest city in Europe was Constantinople, and had likewise been Europe's intellectual capital. After the discovery of the Americas, however, cities like Madrid and Paris started to compete with Constantinople for wealth -- and during the Industrial Revolution, London became Europe's largest and wealthiest city, with the cultural and intellectual prestige that brings. But the privations of the 20th century (including the Great Depression, the Blitz, and suburbanisation) caused London's growth to slow, while Istanbul itself grew to once again be Europe's most populous city -- although it is not Europe's wealthiest, and it doesn't command the prestige or intellectual clout it did at the height of the Byzantine or Ottoman eras.
Istanbul's geography is well-suited to being a metropolis -- but geography isn't the only thing that contributes to city growth. Technology, changing labour relations, the global flow of trade, and other effects of human activity also affect the growth of a city. London -- the capital of a global colonial empire, and the centre of an industrial revolution -- overtook Istanbul in the 19th century, but Istanbul overtook London after Turkey experienced its own urbanisation/industrialisation, and the British Empire had largely been dismantled.
Meanwhile, quite a few cities lost their historical importance due to colonisation. Samarkand and Bukhara come to mind -- both were historic centres of Islamic scholarship and Turco-Persian culture, but their commercial importance declined with the Silk Road. Now, they aren't even the most important cities in Uzbekistan -- that position is held by Tashkent, built as a Russian military outpost, which grew in importance after the construction of the Trans-Caspian Railway.
Bengal's historic commercial hubs of Dhaka, Chittagong, and Sonargaon declined as they competed with the British city of Calcutta; the cities of Ahmedabad and Surat declined as they competed with the British port of Bombay; Malacca, Aceh, and Brunei declined as they competed with British Singapore and Dutch Batavia; etc. And these were very much due to colonial policies & restrictions on trade, as well as just the history of those cities -- e.g., the British East India Company establishing itself in Calcutta before it controlled all of Bengal, and so building its infrastructure around gathering wealth to Calcutta as it expanded. The growth of Calcutta and decline of other Bengali cities was by no means inevitable; it was contingent on the expansion of the British East India Company. Had the French conquered Bengal, its capital might be Chadernagore; had the Dutch, it might be Hooghly-Chinsurah; had it remained Mughal, it might be Dhaka or Murshidabad or Sonargaon. While Bengal is naturally suited to support a massive population, that population wouldn't be centred in Calcutta if not for the EIC.
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